Not for human use, for research purposes only
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Oxytocin - Oxytocin is a 9-amino-acid hypothalamic neuropeptide and oxy

Oxytocin

Oxytocin is a 9-amino-acid hypothalamic neuropeptide and oxytocin-receptor agonist.

Reproductive
In Stock

1 vial · 2 mg total

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Total Price

฿1100

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

~1-6 minutes (plasma)

Oxytocin Receptor Agonist

Nine-amino-acid cyclic neuropeptide with a disulfide bridge

Gq-Coupled Receptor

Signals through phospholipase C and intracellular calcium

Hypothalamic Neuropeptide

Produced in the paraventricular and supraoptic nuclei

Mechanism of Action

Oxytocin is a nine-amino-acid cyclic neuropeptide (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) with a disulfide bridge between the two cysteine residues, produced in the paraventricular and supraoptic nuclei of the hypothalamus. It is an agonist at the oxytocin receptor, a Gq-coupled G-protein coupled receptor signalling through phospholipase C and intracellular calcium. Peripheral oxytocin crosses the blood-brain barrier poorly, which is why central and peripheral compartments are studied separately.

Structure

Oxytocin is a nine-amino-acid cyclic neuropeptide (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) with a disulfide bridge between the cysteine residues at positions 1 and 6. It is produced in the paraventricular and supraoptic nuclei of the hypothalamus and has a molecular mass of roughly 1007 Da.

Oxytocin Receptor Distribution

The oxytocin receptor (OTR) is a Gq-coupled GPCR signalling through phospholipase C and intracellular calcium. It is expressed in:

Limbic system:

  • Amygdala (basolateral and central nuclei)
  • Hippocampus
  • Nucleus accumbens

Hypothalamus:

  • PVN (autoreceptor function)
  • Lateral hypothalamus

Brainstem:

  • Locus coeruleus
  • Dorsal raphe

Pharmacokinetic Notes

Peripheral oxytocin crosses the blood-brain barrier poorly, which is why central and peripheral compartments are studied separately. The plasma half-life is short, reflecting rapid enzymatic degradation by oxytocinase and renal clearance.

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.

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