Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) developed by the Russian Academy of Sciences in the 1990s. It is based on the ACTH(4-7) fragment and stabilised with a Pro-Gly-Pro tail, and it is studied for BDNF and NGF expression in laboratory models.

What is the relationship between Semax and ACTH?

Semax is derived from ACTH(4-7), a fragment of adrenocorticotropic hormone. The full ACTH molecule also triggers cortisol release from the adrenal cortex. By using only the 4-7 fragment and extending it with Pro-Gly-Pro, Semax is reported to retain neurotrophic activity without adrenal stimulation.

How should the vial be stored?

Lyophilised vials are stored at -20 degrees Celsius, protected from light.

Semax

Name: Semax
Brand: Milo-Lab
Availability: InStock

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) built on the ACTH(4-7) fragment, studied for BDNF and NGF expression in laboratory models.

Neuro

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1 vial · 5 mg total

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฿700

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

~1-7 minutes; active metabolites persist longer

ACTH(4-7) Fragment Structure

Met-Glu-His-Phe core of adrenocorticotropic hormone, without the cortisol-releasing portion

BDNF & NGF Expression

Studied for neurotrophin expression in rodent brain tissue

Pro-Gly-Pro Extension

Tripeptide tail slows enzymatic degradation

Mechanism of Action

Semax is a synthetic heptapeptide built on the ACTH(4-7) fragment (Met-Glu-His-Phe) and extended with a Pro-Gly-Pro tail that resists enzymatic breakdown. Stripping the rest of the adrenocorticotropic hormone removes its cortisol-releasing action while retaining neurotrophic signalling. In rodent models Semax is reported to raise brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) through melanocortin-receptor-independent pathways, to modulate dopaminergic and serotonergic transmission, to increase vascular endothelial growth factor (VEGF) expression in neurons and astrocytes, and to lower oxidative-stress markers in low-oxygen models.

What Semax Is

Semax is a synthetic heptapeptide developed in Russia from the ACTH(4-7) fragment (Met-Glu-His-Phe) with a Pro-Gly-Pro extension. It is supplied as a 5mg vial, sold singly or in 25mg and 50mg kits, and is studied in:

BDNF and NGF neurotrophic-signalling studies
Dopaminergic and serotonergic pathway investigations
VEGF expression and angiogenesis in neuronal and astrocyte models
Oxidative-stress marker research in low-oxygen models

Mechanism: Neurotrophic Factor Cascade

BDNF and NGF upregulation: Semax is reported to raise both the mRNA and the protein levels of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) across the hippocampus, frontal cortex, and striatum in rodent studies.

Dopamine and serotonin modulation: Semax is reported to activate dopaminergic neurons in the mesocortical and nigrostriatal pathways and to modulate serotonergic transmission.

VEGF upregulation: In low-oxygen models, Semax increases vascular endothelial growth factor (VEGF) in neurons and astrocytes, a signal associated with angiogenesis.

Oxidative stress markers: Semax is reported to curb superoxide dismutase (SOD) consumption and to lower lipid-peroxidation markers in experimental low-oxygen models.

Standard Semax vs N-Acetyl Semax Amidate

Form	Modifications	Stability
Standard Semax	None	Moderate
N-Acetyl Semax	N-terminal acetyl	Higher
N-Acetyl Semax Amidate	Acetyl + C-terminal amide	Highest

The acetyl and amidate modifications increase lipophilicity and harden the peptide against enzymatic degradation.

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.

Product FAQs

Listed in Blends

Neuro Blend

Semax Selank