DSIP is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from the cerebral venous blood of rabbits. It is studied in neuroendocrine research, including modulation of the hypothalamic-pituitary-adrenal (HPA) axis in stress models. Milo-Lab supplies it as a single 5mg vial for research use.

What is the relationship between DSIP and the HPA axis?

In rodent and cell models, DSIP is reported to modulate the hypothalamic-pituitary-adrenal axis, dampening cortisol responses to stress while leaving resting adrenal output largely unchanged. It has also been reported to influence LH pulsatility, pointing to broader neuroendocrine activity.

Is DSIP structurally stable?

DSIP is notoriously difficult to handle because it tends to cross-link and polymerise in solution. Store the lyophilised powder at 2-8°C.

DSIP

Name: DSIP
Brand: Milo-Lab
Availability: InStock
Rating: 5 (1 reviews)

5.0 (1)

DSIP is an endogenous nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), studied in hypothalamic-pituitary-adrenal (HPA) axis and neuroendocrine research.

Neuro

In Stock

Select Variant

1 vial · 5 mg total

Quantity (vials)

Checking availability…

Total Price

฿900

& moreCrypto −5%Encrypted checkout

For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

~30 minutes

Nonapeptide Structure

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from the cerebral venous blood of rabbits

HPA Axis Modulation

Studied for hypothalamic-pituitary-adrenal signalling in rodent and cell models

Neuroendocrine Models

Studied for LH pulsatility and growth-hormone axis signalling in rodent models

Mechanism of Action

DSIP is a naturally occurring nine-amino-acid neuropeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from the cerebral venous blood of rabbits. In laboratory research it is investigated for activity at hypothalamic targets and for modulation of the hypothalamic-pituitary-adrenal (HPA) axis, including stress-induced cortisol release, without a reported effect on resting adrenal output. Additional reported areas include luteinizing hormone (LH) pulsatility, the growth-hormone (GH) axis and natural killer (NK) cell activity in models.

What DSIP Is

DSIP is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from the cerebral venous blood of rabbits. It has a half-life of roughly 30 minutes and is supplied here as a single 5mg research vial.

Studied Pathways

HPA axis: In rodent and cell models, DSIP is reported to modulate cortisol release after stress. The pattern in the literature is modulation of stress reactivity rather than global suppression, since adrenal steroidogenesis under resting conditions is not meaningfully affected.

GH axis: DSIP is reported to modulate somatotroph activity, and several reports describe altered GH pulsatility.

LH pulsatility: DSIP is reported to influence luteinizing hormone pulse patterns in neuroendocrine models.

NK cell activity: In some models DSIP modulates natural killer cell cytotoxicity.

Research Areas

HPA axis models and stress-physiology research
Cortisol reactivity in rodent and cell models
Neuroendocrine signalling (GH and LH axes)
Neuropeptide structure and stability studies

Storage

Lyophilised vials: store at 2-8°C.

For research purposes only. Not for human consumption.

Product FAQs

Customer Reviews

5.0 (1)

Excellent service and products

Joe Verified

2026-08-27