Pinealon
Pinealon (Glu-Asp-Arg, EDR) is a Khavinson short-peptide bioregulator studied for neuroprotection, melatonin support and reduced neuronal oxidative stress.
Total Price
฿1700
For research & laboratory use only. Not for human consumption.
Half-Life
~1-2 hours
Administration Route
Subcutaneous injection or oral
Pineal Gland Peptide
Khavinson tripeptide targeting pineal gland gene expression
Melatonin Restoration
Supports age-related decline in pineal melatonin production
Neuroprotection
Reduces neuronal oxidative stress and supports glial health
Mechanism of Action
Scientific Research
Ann N Y Acad Sci (2004)
Bull Exp Biol Med (2007)
Neuro Endocrinol Lett (2007)
Mechanism: Nuclear Penetration and Gene Activation
Pinealon’s proposed mechanism involves:
- Cellular uptake via endocytosis or direct membrane penetration (small peptides can enter cells through transporter proteins)
- Nuclear localisation - EDR interacts with histone-associated chromatin
- Binding to promoter regions of pineal-specific genes
- Transcriptional activation of:
- AANAT (arylalkylamine N-acetyltransferase, rate-limiting for melatonin synthesis)
- Nrf2-regulated antioxidant genes (HO-1, SOD, catalase)
- Survival genes in neurons (Bcl-2 family)
Evidence for this mechanism comes from both cell culture studies and animal models showing Pinealon-induced increases in antioxidant enzyme expression and reductions in lipofuscin accumulation.
Lipofuscin and Neuronal Aging
Lipofuscin is a fluorescent waste material that accumulates in post-mitotic cells (neurons, cardiomyocytes) as a result of incomplete lysosomal degradation of oxidised proteins. Its accumulation is a hallmark of cellular aging and is associated with reduced neuronal function. Pinealon has been shown in multiple studies to reduce lipofuscin content in brain tissue of aged animals - suggesting it either reduces oxidative damage that generates lipofuscin or enhances lysosomal/proteasomal clearance.
Combination with Epithalon
The Khavinson group has studied combinations of their peptide bioregulators extensively:
- Epithalon (AEDG): thymus-derived, systemic telomerase activation and immune modulation
- Pinealon (EDR): pineal-derived, brain and melatonin axis support
Together they are reported to produce additive anti-aging effects in both animal models and long-term human observational studies.
Reconstitution and Storage
Reconstitution: reconstitute the vial with bacteriostatic water; swirl gently until dissolved, do not shake. After reconstitution: keep refrigerated, protect from direct light, and use within 28 days.
For research purposes only. Not for human consumption.
Dosing at a Glance
Route
Subcutaneous injection or oral
Frequency
Once daily
Typical research dose
200–400 mcg
Opens the calculator with this peptide preselected. Research reference only.
Product FAQs
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