Pinealon
Pinealon (Glu-Asp-Arg, EDR) is a Khavinson short-peptide bioregulator studied for AANAT and Nrf2-dependent gene expression in cell models.
1 vial · 20 mg total
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Total Price
฿1700
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Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries
Half-Life
~1-2 hours
Pineal Gland Peptide
Khavinson tripeptide targeting pineal gland gene expression
AANAT Gene Expression
Studied for transcription of the rate-limiting melatonin-synthesis enzyme in cell models
Neuronal Cell Models
Studied for antioxidant gene expression in neuronal cell models
Mechanism of Action
Mechanism: Nuclear Penetration and Gene Activation
Pinealon’s proposed mechanism involves:
- Cellular uptake via endocytosis or direct membrane penetration (small peptides can enter cells through transporter proteins)
- Nuclear localisation: EDR interacts with histone-associated chromatin
- Binding to promoter regions of pineal-specific genes
- Transcriptional activation of:
- AANAT (arylalkylamine N-acetyltransferase, rate-limiting for melatonin synthesis)
- Nrf2-regulated antioxidant genes (HO-1, SOD, catalase)
- Survival genes in neurons (Bcl-2 family)
Evidence for this mechanism comes from cell culture studies and animal models reporting increased antioxidant enzyme expression.
Storage
Lyophilised vials: store at -20°C, protected from light.
For research purposes only. Not for human consumption.
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