How does epitalon activate telomerase?

Epitalon is reported to stimulate expression of the telomerase gene (hTERT) in somatic cells that normally show little telomerase activity. Khavinson and colleagues found the peptide binds chromatin and behaves as a transcription modulator, switching on genes linked to cell renewal, so telomeres can be rebuilt rather than progressively shortened.

What does epitalon do besides telomere lengthening?

Beyond telomerase activation, epitalon restores age-related decline in pineal gland melatonin secretion, which helps re-set circadian rhythm and sleep. It also supports hypothalamic-pituitary function and reduces lipid peroxidation, an antioxidant effect. In rodent studies these actions tracked with lower spontaneous tumour incidence and longer lifespan.

What is the sequence of epitalon?

Ala-Glu-Asp-Gly, a four-amino-acid peptide and among the shortest of the bioregulators studied.

How is purity verified?

Each batch ships with a certificate of analysis reporting purity by HPLC and identity by mass spectrometry. It is available on request before ordering.

Epitalon

Name: Epitalon
Brand: Milo-Lab
Availability: InStock

Epitalon (epithalon) is a synthetic Ala-Glu-Asp-Gly tetrapeptide studied for telomerase activation, pineal regulation and longevity research.

Cellular

In Stock

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1 vial · 50 mg total

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Total Price

฿2700

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

Unknown

Telomere Extension

Only peptide with RCT evidence of telomere lengthening

Pineal Gland Regulation

Restores melatonin secretion and circadian rhythm

p53 Expression

Studied for p53 expression in aged tissue models

Mechanism of Action

Epitalon is a four-amino-acid peptide (Ala-Glu-Asp-Gly) that upregulates expression of telomerase reverse transcriptase (hTERT), the catalytic enzyme that rebuilds telomeric DNA at chromosome ends and offsets the telomere shortening tied to cellular senescence. It interacts with chromatin and acts as a transcription modulator on genes governing cell renewal. In parallel it restores pineal gland melatonin secretion, helps normalise the hypothalamic-pituitary axis, and lowers lipid peroxidation, giving it an antioxidant profile. Animal studies report reduced age-related pathology and extended median and maximum lifespan.

Scientific Research

Geroprotective effect of epithalon in elderly subjects (randomized controlled trial)

Neuro Endocrinology Letters (2003)

Effect of Epithalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Biogerontology (2002)

Why Researchers Choose Epitalon

Epitalon (epithalon) is the synthetic Ala-Glu-Asp-Gly tetrapeptide that put telomerase activation on the longevity-research map, and it is studied wherever telomere biology, pineal function and biological-age endpoints intersect:

Telomere length maintenance and telomerase (hTERT) activation studies
Cellular senescence and replicative lifespan research
Pineal gland regulation, melatonin and circadian rhythm investigations
Anti-carcinogenic activity in chemically induced tumour models
Neuroendocrine ageing and hypothalamic-pituitary regulation studies
Oxidative stress and antioxidant pathway research

Reconstitution and Storage

Reconstitution: use bacteriostatic water (typically 1 to 2ml per vial); swirl gently until fully dissolved, do not shake. After reconstitution: keep refrigerated at 2-8°C, use within 28 days, do not freeze or expose to direct light.