MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded inside the mitochondrial 12S rRNA gene. It acts as a signalling peptide that engages the AMPK pathway and nuclear stress-response genes in cell models, which is why it is studied as a mitochondrial signalling research peptide.

Which pathway does MOTS-c act on?

The folate-methionine cycle and the linked de novo purine synthesis. Their inhibition leads to AICAR accumulation, which activates the AMPK pathway.

MOTS-c

Name: MOTS-c
Brand: Milo-Lab
Availability: InStock

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded in the 12S rRNA gene, studied for AMPK pathway signalling in cell models.

MetabolicMitochondrial

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1 vial · 40 mg total

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For research & laboratory use only. Not for human consumption.

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Mitochondrial Hormone

Mitochondria-encoded peptide that regulates nuclear gene expression

AMPK Pathway

Activates AMPK signalling via folate-cycle inhibition and AICAR accumulation

Folate-Methionine Cycle

Acts on the folate-methionine cycle of one-carbon metabolism

Mechanism of Action

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino-acid microprotein encoded within the mitochondrial 12S rRNA gene rather than the nuclear genome. Under metabolic stress it translocates from the mitochondria into the cytoplasm and nucleus. In the cytoplasm it inhibits the folate-methionine cycle and the linked de novo purine synthesis, which allows AICAR to accumulate; rising AICAR activates the AMPK pathway. In the nucleus, MOTS-c is reported to bind antioxidant response elements (AREs) and to act on NRF2-dependent transcription of stress-response and metabolic genes. It is described as a retrograde signal that lets the mitochondrion communicate with the nucleus.

Why Researchers Choose MOTS-c

MOTS-c is one of the first mitochondrial-derived peptides (MDPs) to be characterised, and it has become a reference tool wherever mitochondrial signalling is investigated. It appears across several research lines:

Mitochondrial retrograde signalling and AMPK pathway studies
AICAR accumulation and AMPK activation in cell-based assays
Folate-methionine cycle and one-carbon metabolism studies
Antioxidant response element binding and NRF2-linked transcription in cell models
Mitochondria-derived peptide biology and mitochondria-to-nucleus communication

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.

MOTS-c

Mitochondrial Hormone

AMPK Pathway

Folate-Methionine Cycle

Mechanism of Action

Why Researchers Choose MOTS-c

Storage

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