GHK-Cu (glycyl-L-histidyl-L-lysine bound to copper) is a naturally occurring copper peptide present in human plasma, saliva and other tissues. Plasma levels fall with age, which is why it is studied as a research agent for collagen production, skin rejuvenation and wound healing.

How does GHK-Cu work?

GHK-Cu carries a copper(II) ion that activates dermal fibroblasts to make more collagen and decorin, while signalling VEGF and FGF to grow new blood vessels at repair sites. It also acts as a gene-expression modulator, upregulating tissue-repair pathways and downregulating inflammatory ones.

Why does GHK-Cu need copper to be active?

The copper ion sets the conformation of GHK-Cu and is required for receptor binding, so free GHK without copper has much weaker activity. The copper is tightly chelated and not released as free ions under physiological conditions, which makes it safer than free copper that can generate hydroxyl radicals.

What does GHK-Cu do beyond collagen?

Microarray work by Pickart and Margolina shows GHK-Cu modulates thousands of human genes. Regulated pathways include tissue remodelling (matrix metalloproteinases and their inhibitors), inflammation (TNF-alpha and IL-6 suppression), neurological repair (NGF and BDNF upregulation) and antioxidant defence.

GHK-Cu

Name: GHK-Cu
Brand: Milo-Lab
Availability: InStock
Rating: 5 (4 reviews)

5.0 (4)

GHK-Cu (glycyl-L-histidyl-L-lysine) is a naturally occurring copper-binding tripeptide that drives collagen synthesis, skin repair and wound healing.

DermalCellular

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1 vial · 50 mg total

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฿800

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For research & laboratory use only. Not for human consumption.

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Wound Models

Macrophage and fibroblast migration in wound models

Neuronal Models

Studied in TBI and dopaminergic neuron models

Copper-Binding Tripeptide

Gly-His-Lys with high affinity for Cu(II)

Mechanism of Action

GHK-Cu is a tripeptide that binds a copper(II) ion, and this copper complex is what makes it biologically active. In dermal fibroblasts it upregulates synthesis of collagen types I, III and VI and boosts decorin, the proteoglycan that organises collagen fibrils into ordered structure. It triggers VEGF and FGF release to drive angiogenesis at repair sites, and it attracts macrophages and fibroblasts that clean and rebuild wounded tissue. At the transcriptional level GHK-Cu behaves as a broad gene-expression modulator: microarray work shows it switches on genes tied to tissue remodelling and antioxidant defence while switching off genes linked to inflammation and cancer progression.

Scientific Research

GHK and GHK-Cu: Humankind's forgotten cure?

Annals of the New York Academy of Sciences (2015)

Copper peptide GHK-Cu in collagen synthesis and wound healing

Journal of Aging Research and Clinical Practice (2015)

Why Researchers Choose GHK-Cu

GHK-Cu is the best-characterised copper peptide in skin and regeneration research, valued because it pairs collagen-building activity with broad gene-expression control. It is studied wherever dermal repair, matrix remodelling and anti-ageing biology intersect:

Collagen synthesis and extracellular matrix remodelling studies
Wound healing and angiogenesis research
Skin ageing and dermal fibroblast function investigations
Anti-inflammatory cytokine modulation studies
Gene expression profiling under copper peptide exposure
Neuroprotection research (NGF and BDNF upregulation)
Hair follicle stimulation and follicular biology investigations

Reconstitution and Storage

Reconstitution: use bacteriostatic water (1 to 2ml per vial); swirl gently until fully dissolved, do not shake. After reconstitution: keep refrigerated at 2-8°C and use within 28 days; do not freeze after reconstitution. Protect from direct light.

Vial & calculation

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Customer Reviews

5.0 (4)

Excellent compound for smoother skin and collagen regeneration

Patrick Verified

2026-09-21

Very good product, works well, fast delivery. Recommended Seller

Mr. S. Verified

2026-09-13

Amazing product, and the shipping was very quick!

Tom

2026-03-13

I have been pinning 0.1ml every day for 6 weeks, and the collagen production is off the charts. I supplement with collagen edibles and drink a lot of broth, and people around me are commenting that I have a very fresh glow to my skin. Really recommend GHK-Cu!

Adriana

2025-01-04

Stacks Well With

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