Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a stabilised analogue of the endogenous peptide tuftsin, studied for GABAergic modulation and BDNF expression in laboratory models. Milo-Lab supplies it as lyophilised 5mg research vials.

Which neurotrophic factors does Selank affect in laboratory studies?

Selank increases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus and frontal cortex in rodent studies. BDNF is a neurotrophin involved in long-term potentiation and synaptic plasticity, and it is the main expression readout reported for Selank.

How is purity verified?

Each batch ships with a certificate of analysis reporting purity by HPLC and identity by mass spectrometry. It is available on request before ordering.

Selank

Name: Selank
Brand: Milo-Lab
Availability: InStock
Rating: 5 (1 reviews)

5.0 (1)

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro), a stabilised tuftsin analogue, studied for GABAergic modulation and BDNF expression.

Neuro

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1 vial · 5 mg total

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฿700

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For research & laboratory use only. Not for human consumption.

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Half-Life

~1-2 minutes; active metabolites persist longer

GABAergic Modulation

Studied for modulation of GABAergic transmission in laboratory models

BDNF Expression

Brain-derived neurotrophic factor expression in models

Tuftsin-Derived Structure

Thr-Lys-Pro-Arg-Pro-Gly-Pro: tuftsin extended with a Pro-Gly-Pro sequence

Mechanism of Action

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic analogue of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), extended with a Pro-Gly-Pro sequence that resists enzymatic breakdown. In laboratory models it is reported to modulate GABAergic transmission, upregulate BDNF and GDNF expression in the hippocampus and frontal cortex, lower noradrenaline turnover in the locus coeruleus, and alter serotonin uptake and metabolism in limbic structures.

Structure

Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro: the tuftsin sequence (Thr-Lys-Pro-Arg) extended with a Pro-Gly-Pro tail that slows enzymatic degradation.

Multi-Target Neurochemical Mechanism

Selank’s reported mechanisms in laboratory models involve several parallel pathways:

GABAergic modulation: Selank is reported to enhance the activity of GABAergic interneurons and to potentiate GABA-A receptor signalling.

BDNF and GDNF upregulation: Selank increases mRNA and protein levels of BDNF (brain-derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) in hippocampal and frontal cortex regions in rodent studies. These neurotrophins are involved in synaptic plasticity and neuronal survival.

Locus coeruleus modulation: Reduces noradrenaline turnover in the locus coeruleus, the primary noradrenergic nucleus, in rodent studies.

Serotonin metabolism: Modulates serotonin uptake and metabolism in limbic structures.

Immune modulation (tuftsin-derived): Retains the immunomodulatory properties of the parent peptide tuftsin and is reported to modulate IL-6 and IL-10 balance in cell models.

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.

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Customer Reviews

5.0 (1)

Ordered Melanotan 2 and Selank. Both compounds arrived securely packaged and in perfect condition. Fast delivery, great batch consistency, and reliable quality. Will definitely order again.

Ramina Verified

2026-08-31

Listed in Blends

Neuro Blend

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