PT-141
PT-141 (bremelanotide) is a cyclic heptapeptide analogue of alpha-MSH and a non-selective melanocortin receptor agonist (MC1R, MC3R, MC4R, MC5R).
1 vial · 10 mg total
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Total Price
฿1000
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Half-Life
~2.7 hours
Melanocortin Receptor Agonist
Non-selective agonist at MC1R, MC3R, MC4R and MC5R; MC4R is expressed in the hypothalamus
Short Half-Life
Half-life of roughly 2.7 hours
Cyclic Heptapeptide
Cyclic alpha-MSH analogue derived from the Melanotan 2 scaffold
Mechanism of Action
Structure and Receptor Profile
PT-141 (bremelanotide) is a cyclic heptapeptide analogue of alpha-MSH that differs from Melanotan 2 by a C-terminal free acid instead of the amide. Like Melanotan 2 it is a non-selective melanocortin receptor agonist with activity at MC1R, MC3R, MC4R and MC5R. MC3R and MC4R are G-protein coupled receptors expressed in the hypothalamus.
MC3R vs MC4R
MC4R: Expressed in the hypothalamus, brainstem and limbic system. MC4R couples through Gs to adenylyl cyclase and raises intracellular cAMP. It is also involved in central energy homeostasis.
MC3R: Expressed in the limbic system, where it modulates presynaptic autoinhibition of melanocortin signalling.
Storage
Lyophilised vials: store at -20°C, protected from light.
For research purposes only. Not for human consumption.
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