PT-141
PT-141 (bremelanotide) is a melanocortin MC4R agonist peptide that acts centrally in the brain to drive sexual desire and arousal.
1 vial · 10 mg total
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Total Price
฿1000
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Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries
Half-Life
~2.7 hours
Central MC4R Pathway
MC4R agonist acting in the hypothalamus rather than peripherally
Rapid Onset
Effects within 45-60 minutes; 12-hour activity window
Studied in Both Sexes
Research literature covers male and female models
Mechanism of Action
Scientific Research
Obstet Gynecol (2019)
Ann N Y Acad Sci (2003)
J Sex Med (2006)
Central Mechanism: The Brain Desire Circuit
The distinction between PT-141 and conventional sexual health treatments is fundamental:
Peripheral approach (PDE5 inhibitors): Sildenafil/tadalafil inhibit phosphodiesterase 5, increasing cGMP in vascular smooth muscle → vasodilation → improved genital blood flow. They require sexual stimulation. They treat physical response, not desire.
Central approach (PT-141): Activates MC4R in the medial preoptic area (mPOA) and arcuate nucleus of the hypothalamus. MC4R activation:
- Increases dopamine release in the nucleus accumbens (mesolimbic reward pathway)
- Activates oxytocin neurons in the PVN
- Reduces inhibitory signalling from somatostatin interneurons in the mPOA
The result: intrinsic sexual motivation is increased, independent of external stimulation or vascular status.
MC3R vs MC4R: Different Roles
MC4R: Primary mediator of PT-141’s sexual effects. Expressed in the hypothalamus, brainstem, and limbic system. MC4R knockout mice have markedly reduced sexual behaviour. MC4R is also involved in central energy homeostasis.
MC3R: Expressed in the limbic system and modulates presynaptic autoinhibition of melanocortin signalling. MC3R activation by PT-141 may contribute to the anxiolytic component of its effects.
FDA Approval Context
The bremelanotide Phase 3 programme (RECONNECT trials) enrolled 1267 premenopausal women with HSDD:
- Primary endpoints: satisfying sexual events and distress scores
- Results: significant improvement in both endpoints vs placebo
- Approved in 2019 by the FDA as Vyleesi, an approved medicine distinct from this research material
Storage
Reconstitution: use bacteriostatic water; swirl gently until dissolved, do not shake. After reconstitution: keep refrigerated (2-8°C), protect from light, and use within 30 days.
For research purposes only. Not for human consumption.
Vial & calculation
Calculate concentration and volume from the labelled amount, your final solution volume and a target amount you provide.
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Product FAQs
Customer Reviews
Good product and works well
Well, that's for my girlfriend to decide. I am tipping she's satisfied
Works perfect,100% Recommended
Hi it’s my 3rd order and I do see a benefit to my sexual insensitivity issue . It is a great thing to have this option when so many other things have failed/ I recommended to a friend of mine who is not a And he boasted how fabulous his results were: what I love about this is the mental connection rather than an artificial Viagra improvement which does not accentuate the orgasm but this product pt does . So Thank You for letting me remain a grateful customer
This peptide is supposed to enhance libido. I'd say this is one of the minor effects. The main effect is an improvement in mood and energy. After a subcutaneous injection, you feel a warm sensation for about 40 minutes, and after 30 minutes, you start to feel a little nauseous and it's best to lie down. But this numbing effect completely wears off after an hour and a half, and the rest of the time, you feel more energetic and active. The more times you use this peptide, the less side effects.
Very legit, very good stuff. You can not go wrong ordering from MILO.
It worked very well, I'm impressed with it. The side effect for me was headaches. If I can overcome the headache problem, I will buy more.
It works like a charm.
Mixed it into a nasal spray bottle with BAC water. Got a nice effect! I tried a higher dose and it resulted in an upset stomach. 5 days delivery to Isan.
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