Kisspeptin is a neuropeptide encoded by the KISS1 gene that sits at the top of the reproductive hormone axis. Kisspeptin-10, its active decapeptide fragment, binds the GPR54 receptor on hypothalamic GnRH neurons and triggers pulsatile GnRH release. It is studied as an upstream regulator of the HPG axis.

How do KNDy neurons regulate the GnRH pulse?

Kisspeptin neurons in the arcuate nucleus (KNDy neurons) act as pulse generators of the reproductive axis, releasing kisspeptin in synchronised bursts that drive a GnRH pulse roughly every 60 to 90 minutes. This pulsatile rhythm is essential, because continuous GnRH instead desensitises the pituitary.

What is the difference between kisspeptin-10 and kisspeptin-54?

Kisspeptin-54 is the full-length processed form of 54 amino acids produced in peripheral tissue. Kisspeptin-10 is the C-terminal decapeptide (residues 45 to 54), the minimum sequence needed for GPR54 binding and full biological activity. Kisspeptin-10 is preferred in research for its smaller size and equivalent receptor potency.

Where can I buy kisspeptin-10 for research?

Milo-Lab ships kisspeptin-10 worldwide as lyophilised 5mg vials, singly or in 25mg/50mg multi-vial kits. It is supplied strictly as a research chemical for laboratory use, not for human administration.

Kisspeptin

Name: Kisspeptin
Brand: Milo-Lab
Availability: InStock

Kisspeptin-10 is the C-terminal decapeptide of the KISS1-encoded neuropeptide kisspeptin and a GPR54 (Kiss1R) agonist acting on hypothalamic GnRH neurons.

ReproductiveEndocrine

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1 vial · 5 mg total

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฿700

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

~4 minutes (plasma)

GnRH Pulse Generator

GPR54 agonist acting on hypothalamic GnRH neurons

HPG Axis Signalling

Acts upstream of pituitary gonadotroph LH and FSH release

Limbic Signalling

Activity in limbic and hypothalamic circuits

Mechanism of Action

Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, the neuropeptide encoded by the KISS1 gene. It binds the GPR54 receptor (also called Kiss1R) on hypothalamic GnRH neurons with nanomolar affinity and triggers GnRH release into the pituitary portal circulation. The GnRH signal acts on pituitary gonadotrophs, which release luteinising hormone (LH) and follicle-stimulating hormone (FSH). Because kisspeptin neurons in the arcuate nucleus act as the endogenous pulse generator of the entire hypothalamic-pituitary-gonadal (HPG) axis, kisspeptin-10 lets researchers probe the axis at its upstream control point rather than at the pituitary or gonad.

Research Overview

Kisspeptin-10 engages the GPR54 receptor on hypothalamic GnRH neurons, the natural control point of the hypothalamic-pituitary-gonadal (HPG) axis. That makes it a probe for studies on GPR54 receptor pharmacology, GnRH pulsatility and gonadotropin (LH/FSH) signalling.

The KNDy Neuron Oscillator

The kisspeptin neurons that govern pulsatile GnRH release are the KNDy neurons (Kisspeptin / Neurokinin B / Dynorphin) of the arcuate nucleus (ARC) in the hypothalamus. Three co-expressed signals create the rhythm:

Kisspeptin is the output signal, activating GnRH neurons through GPR54.
Neurokinin B (NKB) acts as the auto-synchroniser, hitting NK3R on neighbouring KNDy neurons so the population fires its kisspeptin burst together.
Dynorphin is the auto-inhibitor, acting on the kappa-opioid receptor (KOR) to shut each burst down and reset the cycle.

Together this oscillator sets the roughly 60 to 90 minute pulse interval of GnRH secretion.

Receptor-Level Signalling Sequence

Kisspeptin-10 binds GPR54 on GnRH neurons.
GnRH is released into the pituitary portal circulation.
Pituitary gonadotrophs respond with release of LH.
Pituitary gonadotrophs also release FSH, with smaller amplitude and slower kinetics.

Research Areas

HPG axis signalling studies
GnRH pulse-generator mapping
GPR54 (Kiss1R) receptor pharmacology

Kit Contents and Storage

Milo-Lab supplies kisspeptin-10 as lyophilised 5mg vials, offered as a single vial or as 25mg (5 x 5mg) and 50mg (10 x 5mg) kits.

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.