Cerebrolysin
Cerebrolysin is a porcine brain protein hydrolysate of low molecular weight neuropeptides and amino acids, studied in neurotrophic-factor signalling research.
5 vials × 60 mg · 300 mg total
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฿3900
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Half-Life
Active fractions have varied half-lives
Neurotrophic Complex
Mimics BDNF, NGF and GDNF, 3 key brain growth factors
Porcine-Derived Peptide Complex
Low molecular weight peptide fractions and free amino acids from enzymatic hydrolysis of porcine brain proteins
BBB Crossing Peptides
Small peptide fractions cross blood-brain barrier via transporters
Mechanism of Action
What Cerebrolysin Is
Cerebrolysin is a multi-fraction neurotrophic peptide complex obtained by enzymatic hydrolysis of purified porcine brain proteins. The box of five 60mg vials is studied in neurotrophic-signalling research:
- Neurotrophic-factor mimicry across BDNF, NGF, GDNF and NT-3 pathways
- Trk-family receptor (TrkB, TrkA) and RET activation
- MAPK/ERK and PI3K/Akt signalling in neuronal cell models
- Synaptic plasticity and long-term potentiation (LTP) studies
- Adult neurogenesis and axonal-growth investigations
Neurotrophic Mechanism
Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) are core survival and plasticity signals for neurons. They are studied in neuronal survival under stress, long-term potentiation (LTP), adult neurogenesis in the hippocampal dentate gyrus, and axonal growth in cell and animal models.
Full-length neurotrophins (BDNF around 27 kDa, NGF around 26 kDa) are too large to cross the blood-brain barrier. Cerebrolysin’s low molecular weight peptide fractions are reported to pass the barrier through amino acid and small peptide transporters, and then to activate TrkB (the BDNF receptor), TrkA (the NGF receptor) and RET (the GDNF co-receptor). The resulting MAPK/ERK, PI3K/Akt and PLC-gamma signalling is associated with neuronal survival, synaptic plasticity and neurogenesis in these models.
Cerebrolysin vs Isolated Peptides (Semax, Selank, P21)
| Feature | Cerebrolysin | Isolated peptides (semax, selank, P21) |
|---|---|---|
| Composition | Multi-fraction complex | Single defined peptide |
| Mechanism | Multiple neurotrophic pathways | Specific (Semax: ACTH(4-7)-derived; Selank: tuftsin-derived; P21: CNTF-derived) |
| BBB crossing | Via transporters | Varies by compound |
For research purposes only. Not for human consumption.
Product FAQs
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