5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase). By blocking NNMT it preserves cellular NAD+ and SAM, which makes it a research compound for NAD+ and methylation-pathway studies. Milo-Lab supplies it as a single 50mg vial.

How does 5-Amino-1MQ work?

NNMT consumes SAM to convert nicotinamide into 1-methylnicotinamide, depleting both SAM and NAD+. 5-Amino-1MQ inhibits NNMT, so NAD+ and SAM stay available. Higher NAD+ activates SIRT1, and in cultured adipocyte models reduced NNMT activity is associated with lower adipocyte differentiation and lipid accumulation.

How does 5-Amino-1MQ differ from NMN or NR?

NMN and NR are NAD+ precursors that add biosynthetic substrate. 5-Amino-1MQ instead acts on NAD+ consumption by blocking the NNMT pathway, and it also preserves SAM for methylation reactions. The two mechanisms act at different points of NAD+ metabolism.

How should it be stored?

Protected from light and moisture, sealed. The certificate of analysis states the tested storage period for the batch.

5-Amino-1MQ

Name: 5-Amino-1MQ
Brand: Milo-Lab
Availability: InStock

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in cell models of NAD+ and S-adenosylmethionine (SAM) metabolism.

MetabolicCellular

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1 vial · 50 mg total

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฿1700

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For research & laboratory use only. Not for human consumption.

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NNMT Enzyme Inhibitor

Inhibits nicotinamide N-methyltransferase in adipocyte models

Adipocyte Gene Expression

Transcriptional markers studied in adipocyte cell models

NAD+ Pathway

Raises NAD+ by inhibiting methylation consumption

Mechanism of Action

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT normally consumes S-adenosylmethionine (SAM) to methylate nicotinamide into 1-methylnicotinamide, a reaction that drains both SAM and NAD+ from the cell. By blocking this enzyme, 5-Amino-1MQ keeps NAD+ and SAM available at the same time. Higher NAD+ activates sirtuins, especially SIRT1, while preserved SAM supports the cell methylation cycle. In cultured adipocyte models, NNMT inhibition is associated with lower adipocyte differentiation and lipid accumulation. The compound is studied as an NNMT inhibitor that acts by reducing NAD+ consumption rather than by supplying a precursor.

Why Researchers Choose 5-Amino-1MQ

5-Amino-1MQ is one of the few small-molecule NNMT inhibitors available for research. It acts on the consumption side of NAD+ metabolism by blocking NNMT, rather than by supplying a precursor. That distinct mechanism makes it useful across several lines of metabolic pathway work:

NNMT enzyme biology and downstream metabolic pathway studies
NAD+ metabolism, consumption-side versus precursor-side mechanisms, in cell models
S-adenosylmethionine (SAM) availability and methylation-cycle research
Adipocyte differentiation and lipid accumulation in cell models
Sirtuin (SIRT1) signalling downstream of NAD+ availability

Storage

Storage: keep the vial sealed and protected from light and moisture.

For research purposes only. Not for human consumption.

5-Amino-1MQ

NNMT Enzyme Inhibitor

Adipocyte Gene Expression

NAD+ Pathway

Mechanism of Action

Why Researchers Choose 5-Amino-1MQ

Storage

Product FAQs

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