5-Amino-1MQ - 5-Amino-1MQ is a small-molecule NNMT inhibitor that raises N

5-Amino-1MQ

5-Amino-1MQ is a small-molecule NNMT inhibitor that raises NAD+ and SAM to support fat-cell metabolism, insulin sensitivity and healthy aging research.

Fat LossMuscle
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1 vial · 50 mg total

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Total Price

฿1700

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Administration Route

Subcutaneous injection

NNMT Enzyme Inhibitor

Blocks fat cell programming enzyme to reverse obesity

Adipocyte Reprogramming

Converts white fat to metabolically active brown fat

NAD+ Pathway

Raises NAD+ by inhibiting methylation consumption

Mechanism of Action

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT normally consumes S-adenosylmethionine (SAM) to methylate nicotinamide into 1-methylnicotinamide, a reaction that drains both SAM and NAD+ from the cell. By blocking this enzyme, 5-Amino-1MQ keeps NAD+ and SAM available at the same time. Higher NAD+ activates sirtuins, especially SIRT1, while restored SAM supports the cell methylation cycle. In adipocyte models, NNMT inhibition lowers fat-cell differentiation and lipid accumulation, which is why the compound is studied as a NAD+ booster that works by reducing consumption rather than by adding a precursor.

Scientific Research

Why Researchers Choose 5-Amino-1MQ

5-Amino-1MQ is one of the few small-molecule NNMT inhibitors available for research, and it raises NAD+ by blocking consumption rather than by feeding a precursor. That distinct mechanism makes it useful across several lines of metabolic and longevity work:

  • NNMT enzyme biology and downstream metabolic pathway studies
  • NAD+ elevation mechanisms independent of NMN/NR precursor supplementation
  • S-adenosylmethionine (SAM) availability and methylation-cycle research
  • Adipocyte metabolism, fat-cell differentiation and lipid accumulation studies
  • Insulin sensitivity and glucose metabolism research
  • Comparative NNMT inhibition vs. NMN/NR booster protocols

Reconstitution and Storage

Reconstitution: use bacteriostatic water, or a 5 to 10% DMSO-in-water mix where greater solubility is needed. Swirl gently until dissolved, do not shake. After reconstitution: keep refrigerated and use within 14 days.

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