Glutathione

Why Researchers Choose Glutathione

Glutathione (GSH) is the master intracellular antioxidant, and it is studied wherever cellular redox balance, hepatic conjugation chemistry or melanin biochemistry matter. Because oral GSH is poorly absorbed, injectable glutathione (supplied by Milo-Lab as a 1500mg vial) is the preferred form for research that needs reliable systemic exposure.

Research Applications

• Oxidative stress biomarker modulation studies
• Hepatic detoxification capacity and phase II enzyme activity research
• Immune cell function and cytotoxicity investigations
• Melanin synthesis inhibition and skin pigmentation research
• Age-associated decline of intracellular GSH concentration
• Comparative pharmacokinetics of parenteral and oral GSH

How Glutathione Works

Glutathione is a tripeptide of glutamate, cysteine and glycine, and its reactive thiol (-SH) group is what makes it the cell’s primary line of antioxidant defence. It neutralises reactive oxygen species directly and serves as the electron donor for glutathione peroxidase enzymes that detoxify peroxides. In the liver it conjugates to toxins and xenobiotics during phase II detoxification, marking them for excretion. In melanocytes it shifts pigment synthesis from darker eumelanin toward lighter phaeomelanin and inhibits tyrosinase, which is the basis for its use in skin-pigmentation research. Because oral glutathione is largely broken down before absorption, injectable delivery is preferred wherever reliable systemic levels are required.

Storage and Reconstitution

Reconstitution: use sterile water for injection or normal saline immediately before use (glutathione is unstable once dissolved); for dilution work, 50-250ml saline is the range reported in the literature; handle promptly. After reconstitution: use within 4 hours for IV, or within 24 hours if refrigerated for subcutaneous use. Protect from light.