How does cagrilintide differ from semaglutide?

Cagrilintide binds amylin and calcitonin receptors, not the GLP-1 or GIP receptors. It belongs to a separate receptor system rather than being a stronger version of the incretin pathway.

What receptors does cagrilintide bind?

Amylin receptors, which are formed by the calcitonin receptor paired with RAMP1, RAMP2 or RAMP3 subunits, and the calcitonin receptor itself. That makes it a dual amylin and calcitonin receptor agonist.

How is purity verified?

Each batch ships with a certificate of analysis reporting purity by HPLC and identity by mass spectrometry. It is available on request before ordering.

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Cagrilintide

Name: Cagrilintide
Brand: Milo-Lab
Availability: InStock

Cagrilintide is a long-acting acylated amylin analogue and dual amylin and calcitonin receptor agonist. Research compound, supplied as lyophilised powder.

MetabolicEndocrine

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1 vial · 10 mg total

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฿3900

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For research & laboratory use only. Not for human consumption.

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Half-Life

Long-acting (acylated, albumin-bound)

Amylin Receptor Agonist

Non-incretin receptor pathway, separate from GLP-1

Dual Receptor Binding

Amylin receptor complexes and the calcitonin receptor itself

Acylated Long-Acting

Fatty-acid side chain extends plasma exposure over native amylin

Mechanism of Action

Amylin is co-secreted with insulin by pancreatic beta cells and signals through amylin receptors, formed by the calcitonin receptor paired with RAMP1, RAMP2 or RAMP3 subunits, concentrated in the area postrema of the hindbrain. Cagrilintide is an acylated long-acting analogue: its fatty-acid side chain binds albumin reversibly, which extends plasma exposure well beyond that of native amylin. It also retains affinity for the calcitonin receptor itself, making it a dual amylin and calcitonin receptor agonist.

Scientific Research

Coadministered cagrilintide and semaglutide in adults with overweight or obesity (REDEFINE 1)

New England Journal of Medicine (2025)

Why Researchers Choose Cagrilintide

Cagrilintide is an acylated amylin analogue studied wherever amylin and calcitonin receptor signalling outside the incretin system is the question:

Amylin and calcitonin receptor pharmacology
Non-incretin receptor pathways and mechanism comparisons
Amylin receptor expression in the area postrema and hypothalamus
Receptor-level comparison with the GLP-1 receptor pathway
Aggregation and albumin-binding properties of acylated amylin analogues

How Cagrilintide Works

Amylin is co-secreted with insulin by pancreatic beta cells and signals through amylin and calcitonin receptor complexes in the area postrema and hypothalamus. Native amylin aggregates readily and clears within minutes, which limits its use where extended plasma exposure is needed. Cagrilintide is an acylated analogue engineered around both problems: the sequence resists aggregation, and a lipid side chain binds albumin to extend plasma exposure well beyond that of native amylin.

Amylin receptor signalling operates independently of the GLP-1 receptor, so the two are studied as separate receptor systems.

Cagrilintide vs GLP-1 and Multi-Agonist Peptides

	Cagrilintide	Semaglutide
Receptor target	Amylin / calcitonin	GLP-1
Pathway	Non-incretin	Incretin
Plasma half-life	Extended (acylated)	Extended (acylated)

Cagrilintide is the compound of interest when the research question concerns amylin receptor signalling itself, or when the interaction between receptor systems is being modelled.

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.