Tesamorelin

Research Overview

Tesamorelin is a stabilised analogue of full-length GHRH(1-44). An N-terminal trans-3-hexenoyl group blocks DPP-4 cleavage. Common research areas:

• GHRH receptor pharmacology and Gs/cAMP signalling in pituitary somatotrophs
• Growth hormone and IGF-1 axis investigations using a pulsatile GHRH receptor stimulus
• Structure and stability work on N-terminally modified GHRH analogues
• Comparison with the GHRH(1-29) fragment sermorelin and with CJC-1295

Mechanism: GHRH Receptor Signalling

1. Tesamorelin binds the GHRH receptor on pituitary somatotrophs
2. Gs coupling activates adenylyl cyclase and raises cAMP
3. PKA signalling drives GH gene transcription and secretion
4. Growth hormone binds the GH receptor and signals through JAK2-STAT5, and hepatic IGF-1 expression follows

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.

Ordering Tesamorelin in Thailand

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