TB-500 - TB-500 is a synthetic Thymosin Beta-4 fragment, a regenerati
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TB-500

TB-500 is a synthetic Thymosin Beta-4 fragment, a regenerative research peptide that drives systemic tissue repair via actin regulation.

Recovery
In Stock

1 vial · 10 mg total

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Total Price

฿1600

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

~8-10 days (systemic circulation)

Administration Route

Subcutaneous injection

Systemic Tissue Repair

Actin sequestration enables cell migration to injury sites

Cardiac Muscle Healing

Strong evidence in cardiac ischaemia and post-MI repair

Anti-Inflammatory

Downregulates TNF-α and IL-6 at wound sites

Effect Timeline

Start - Week 1

Systemic anti-inflammatory effect; reduced stiffness

Week 2

Improved mobility; cellular migration to damaged tissue

Week 4

Functional healing of soft tissue; muscle repair accelerated

Week 8

Full systemic tissue restoration; chronic injury improvement

Mechanism of Action

TB-500 reproduces the active region of Thymosin Beta-4 (TB4), a 43-amino-acid peptide expressed in almost every cell type. Its core function is binding free G-actin monomers, which fine-tunes actin polymerisation and lets cells migrate quickly toward sites of injury. Through this actin-regulating activity TB-500 mobilises repair cells systemically, increases expression of growth-factor receptors, and supports new blood-vessel formation (angiogenesis) by upregulating matrix metalloproteinases such as MMP-2. It also dampens local inflammation, with research linking Thymosin Beta-4 to reduced NF-kB signalling and lower pro-inflammatory cytokine output. Unlike locally acting compounds, TB-500 circulates and acts body-wide, which makes it a reference peptide for soft-tissue, cardiac and wound-healing models.

Scientific Research

Why Researchers Choose TB-500

TB-500 is the research-grade Thymosin Beta-4 fragment used wherever systemic, body-wide tissue repair is the question rather than a single injury site. By regulating actin and mobilising regenerative cells through the circulation, it has become a reference peptide across several repair-focused models:

  • Soft-tissue, tendon and ligament healing studies
  • Cardiac repair and post-ischaemic cardiomyocyte survival research
  • Wound healing and dermal regeneration models
  • Angiogenesis and endothelial progenitor cell mobilisation
  • Anti-inflammatory and cytokine-modulation investigations
  • Neuro-repair work, including oligodendrocyte differentiation and myelination

TB-500 vs BPC-157: Complementary Repair Pathways

TB-500 and BPC-157 are among the most frequently co-administered repair peptides in research because they act through distinct mechanisms that overlap well:

MechanismBPC-157TB-500
AngiogenesisVEGF upregulationMMP-2, VEGF
Cell migrationFAK-PaxillinActin sequestration
Primary targetLocal (injury site)Systemic
Half-life~4 hours~8-10 days

BPC-157 concentrates on local vascular and fibroblast activity at the injury site, while TB-500 mobilises repair cells throughout the body. Used together they cover both ends of the healing cascade. See the Wolverine Stack BPC-157 + TB-500 kit for bundled pricing.

Reconstitution and Storage

Reconstitution: use bacteriostatic water; swirl gently until dissolved, do not shake. After reconstitution: store refrigerated, use within 30 days, and protect from direct light.

For research purposes only. Not for human consumption. For a side-by-side research overview, read BPC-157 vs. TB-500.

Vial & calculation

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Product FAQs

Stacks Well With

Used in Research Stacks

Recovery & Repair Stack

BPC-157 500 mcg TB-500 2.5 mg

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