KPV (Lys-Pro-Val) is a research tripeptide made of the final three amino acids at the C-terminal end of alpha-melanocyte stimulating hormone (alpha-MSH). Although alpha-MSH is a 13-amino-acid hormone, studies show this short fragment keeps much of its NF-kB-related signalling activity, which makes KPV a compact research tool for signalling studies in cell models.

How does KPV act on NF-kB signalling?

In cell studies KPV is reported to block the NF-kB transcription factor from entering the cell nucleus and to dampen MAP kinase signalling, which lowers pro-inflammatory cytokine production in cultured cells. The NF-kB effect has also been described in intestinal epithelial cell models.

In which research models is KPV studied?

KPV is studied in intestinal epithelial cell models, in keratinocyte cell models, and in neuroinflammation models. Its reported ability to cross the blood-brain barrier is the reason for interest in the latter.

How should the vial be stored?

Lyophilised vials are stored at -20 degrees Celsius, protected from light.

KPV - KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH,

KPV

Name: KPV
Brand: Milo-Lab
Availability: InStock

KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH, studied in NF-kB and MAP kinase signalling research. Molecular mass about 342.4 Da.

TissueImmune

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1 vial · 10 mg total

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฿1000

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For research & laboratory use only. Not for human consumption.

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Half-Life

~2-3 hours

Alpha-MSH Fragment

C-terminal tripeptide (Lys-Pro-Val) of alpha-MSH, reported to inhibit NF-κB signalling in cell models

Intestinal Epithelial Models

NF-kB signalling markers in intestinal epithelial cell models

Keratinocyte Cell Models

Inflammatory signalling markers in keratinocyte cultures

Mechanism of Action

KPV is the three-amino-acid C-terminal fragment (Lys-Pro-Val) of alpha-melanocyte stimulating hormone (alpha-MSH), a 13-amino-acid peptide hormone. In cell studies it is reported to reduce pro-inflammatory cytokine output by preventing NF-kB from translocating into the cell nucleus and by dampening MAP kinase signalling cascades. In intestinal epithelial cell models it antagonises the NF-kB pathway directly. The peptide is reported to cross the blood-brain barrier, and it has been examined as a tool for studying microglia-related signalling in neuroinflammation models.

About KPV

KPV is the C-terminal tripeptide (Lys-Pro-Val, molecular mass about 342.4 Da) of alpha-MSH, a 13-amino-acid peptide hormone. Studies show that this short fragment retains much of the parent hormone’s NF-kB-related signalling activity in cell models.

Research Areas

The KPV 10mg vial is studied in three main areas:

Intestinal epithelial models: KPV is studied in intestinal epithelial cell cultures, where inflammation markers and epithelial barrier markers are measured.

Keratinocyte cell models: KPV is investigated for its effect on inflammatory signalling in keratinocyte cultures.

Neuroinflammation models: Its reported blood-brain barrier penetration has opened research into microglial signalling in neuroinflammation models.

Storage

Lyophilised vials: store at -20°C, protected from light.

For research purposes only. Not for human consumption.

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