Melanotan 2
Melanotan 2 (MT-II) is a synthetic cyclic lactam analogue of alpha-MSH with agonist activity at the MC1R, MC3R, MC4R and MC5R receptors. Research compound.
1 vial · 10 mg total
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Total Price
฿800
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Half-Life
~33 minutes
Alpha-MSH Analogue
Synthetic cyclic lactam analogue of alpha-melanocyte-stimulating hormone
Four Receptor Subtypes
Binds MC1R, MC3R, MC4R and MC5R without selectivity
Cyclic Lactam Structure
cyclo[Nle4,Asp5,D-Phe7,Lys10]-alpha-MSH(4-10)
Mechanism of Action
Research Overview
Melanotan 2 (MT-II) is a reference tool compound for the melanocortin system, because a single cyclic alpha-MSH analogue engages four receptors at once. That breadth makes it a frequent subject across several research areas:
- MC1R signalling and cAMP coupling in melanocyte models
- MC3R and MC4R as central melanocortin receptors
- MC5R in exocrine tissue
- Comparisons with PT-141 (bremelanotide), the C-terminal free-acid analogue
- Structure-activity work on cyclic versus linear melanocortin peptides
Melanotan 2 Receptor Pharmacology
The four melanocortin receptors relevant to MT-II research and where each is expressed:
| Receptor | Primary Location | Signalling Context |
|---|---|---|
| MC1R | Melanocytes, skin | Gs/cAMP coupling in melanocytes |
| MC3R | Hypothalamus, limbic | Central melanocortin receptor |
| MC4R | Hypothalamus, brainstem, spinal cord | Central melanocortin receptor |
| MC5R | Exocrine glands, adrenal cortex | Exocrine tissue receptor |
MC1R is expressed on melanocytes, while MC3R and MC4R are central receptors. The absence of receptor selectivity is the defining pharmacological feature of MT-II.
Scientific Significance
Melanotan 2 engages MC1R, MC3R, MC4R and MC5R without selectivity. It is the parent compound of PT-141 (bremelanotide) and remains a reference compound in melanocortin receptor research. It is not an approved medicine.
Storage
Lyophilised vials: store at -20°C, protected from light.
For research purposes only. Not for human consumption.
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