Ipamorelin + CJC-1295 Blend
Ipamorelin + CJC-1295 (no DAC) is a GHRH/GHRP peptide blend that pairs two receptor pathways to amplify natural growth hormone (GH) release.
Total Price
฿1700
For research & laboratory use only. Not for human consumption.
Half-Life
CJC-1295 no DAC: ~30min; Ipamorelin: ~2h
Administration Route
Subcutaneous injection
Optimised GH Stack
GHRH + GHRP combination produces 10x more GH than either alone
Lean Mass + Fat Loss
GH pulse drives IGF-1 synthesis and simultaneous lipolysis
Anti-Aging Protocol
Most widely studied peptide combination for GH restoration
Effect Timeline
Sleep quality dramatically improves within first week
Body composition shifts; recovery between sessions faster
Visible lean mass gain; fat loss around midsection
Peak GH/IGF-1 optimisation; significant physique change
Start — Week 1
Sleep quality dramatically improves within first week
Week 4
Body composition shifts; recovery between sessions faster
Week 8
Visible lean mass gain; fat loss around midsection
Week 16
Peak GH/IGF-1 optimisation; significant physique change
Mechanism of Action
Why Researchers Choose the Ipamorelin + CJC-1295 Blend
This GHRH plus GHRP combination is one of the most studied approaches to amplifying endogenous growth hormone. Pituitary somatotrophs sit at the crossing point of several regulatory inputs:
Stimulatory:
- GHRH (via the GHRH receptor, Gs-coupled) raises cAMP and activates PKA
- Ghrelin and GHRPs (via GHS-R1a, Gq-coupled) raise intracellular Ca2+ and drive vesicle exocytosis
Inhibitory:
- Somatostatin (via SSTR, Gi-coupled) opposes cAMP and restrains release
CJC-1295 without DAC and Ipamorelin each engage one of the two stimulatory arms. When the GHRH receptor and GHS-R1a fire at the same time, the cAMP signal sensitises the secretory machinery while the calcium signal triggers vesicle fusion. Two independent amplification pathways converge on a single secretory event, so the GH pulse the blend produces is greater than either peptide can generate on its own.
Why the release stays pulsatile: CJC-1295 no DAC (roughly 30 minute half-life) and Ipamorelin (roughly 2 hour half-life) both clear quickly, so somatostatin tone returns between doses and the natural GH rhythm is maintained. This is the key contrast with CJC-1295 carrying the DAC modification (multi-day half-life), which holds GH elevated in a more constant, less pulsatile way.
Downstream Effects of a Stronger GH Pulse
- IGF-1 output: every GH pulse stimulates hepatic IGF-1 synthesis, the main anabolic mediator
- Fat metabolism: GH activates hormone-sensitive lipase in adipocytes, raising lipolysis
- Protein synthesis: IGF-1 promotes mTOR signalling in muscle tissue
- Sleep architecture: GH is secreted mainly during slow-wave sleep, and stronger pulses are linked to deeper SWS
- Connective tissue: IGF-1 supports collagen synthesis in tendons and cartilage
Reconstitution and Kit Contents
Milo-Lab supplies the blend as a single 5mg vial containing both CJC-1295 without DAC and Ipamorelin. Bacteriostatic water is sold separately.
Reconstitution: use bacteriostatic water; swirl gently until fully dissolved, do not shake. After reconstitution: keep refrigerated at 2-8°C, protected from light.
For research purposes only. Not for human consumption.
Dosing at a Glance
Route
Subcutaneous injection
Frequency
1-2x daily
Typical research dose
200–500 mcg
Opens the calculator with this peptide preselected. Research reference only.
Product FAQs
Stacks Well With
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Related Products
CJC-1295 (no DAC)
CJC-1295 without DAC (Mod GRF 1-29) is a short-acting GHRH analogue that triggers pulsatile growth hormone release for muscle, recovery and fat-loss research.
Ipamorelin
Ipamorelin is a selective pentapeptide growth hormone secretagogue (GHRP) that triggers clean, pulsatile GH release without spiking cortisol or prolactin.