What is the Ipamorelin + CJC-1295 blend?

It is a research peptide combination that pairs CJC-1295 without DAC, a GHRH analog, with Ipamorelin, a selective growth-hormone-releasing peptide (GHRP). Milo-Lab supplies it as a single 10mg vial containing 5mg of each peptide. Together the two peptides stimulate the pituitary through separate receptor pathways to produce a larger, still-pulsatile growth hormone release than either alone.

Why is the combination more effective than either peptide alone?

CJC-1295 acts on the GHRH receptor (Gs/cAMP) while Ipamorelin acts on the ghrelin receptor (GHS-R1a/Gq/Ca2+), two independent second-messenger systems. Activating both at once lets the signals converge on the same somatotroph, so the resulting GH pulse is greater than additive. This GHRH plus GHRP pairing is a long-standing approach in growth hormone secretagogue research.

How is the blend reconstituted and injected?

The blend ships as a single 10mg vial holding 5mg of each peptide. Add bacteriostatic water, swirl gently until dissolved, and do not shake. Both compounds are stable in the same solution, so one subcutaneous injection delivers the GHRH and GHRP components together.

When is the blend typically administered?

Research protocols commonly dose immediately before sleep, to reinforce the natural nocturnal GH surge, or on waking in a fasted state. High blood glucose and insulin blunt GH release through somatostatin feedback, so fasted timing gives the cleanest GH response.

How does the no-DAC version differ from CJC-1295 with DAC?

CJC-1295 without DAC has a short half-life (around 30 minutes), so GH stays pulsatile and somatostatin tone recovers between doses. The DAC version lasts several days and produces a more sustained, less pulsatile GH elevation. This blend uses the no-DAC form to keep the natural rhythm intact.

Ipamorelin + CJC-1295 Blend

Name: Ipamorelin + CJC-1295 Blend
Brand: Milo-Lab
Availability: InStock
Rating: 5 (3 reviews)

5.0 (3)

Ipamorelin + CJC-1295 (no DAC) is a GHRH/GHRP peptide blend that pairs two receptor pathways to amplify natural growth hormone (GH) release.

GH Boost

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1 × 10mg vial (5mg + 5mg)

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Total Price

฿1700

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

CJC-1295 no DAC: ~30min; Ipamorelin: ~2h

Administration Route

Subcutaneous injection

Optimised GH Stack

GHRH + GHRP combination produces 10x more GH than either alone

Lean Mass + Fat Loss

GH pulse drives IGF-1 synthesis and simultaneous lipolysis

Anti-Aging Protocol

Most widely studied peptide combination for GH restoration

Effect Timeline

Start

Sleep quality dramatically improves within first week

Week 4

Body composition shifts; recovery between sessions faster

Week 8

Visible lean mass gain; fat loss around midsection

Week 16

Peak GH/IGF-1 optimisation; significant physique change

Start - Week 1

Sleep quality dramatically improves within first week

Week 4

Body composition shifts; recovery between sessions faster

Week 8

Visible lean mass gain; fat loss around midsection

Week 16

Peak GH/IGF-1 optimisation; significant physique change

Mechanism of Action

This blend pairs a GHRH analog with a selective GHRP to drive growth hormone from two angles at once. CJC-1295 without DAC binds the pituitary GHRH receptor (Gs-coupled), raising cAMP and priming somatotrophs to release GH. Ipamorelin binds the ghrelin receptor (GHS-R1a, Gq-coupled), raising intracellular calcium that triggers exocytosis of GH secretory granules. Because the two peptides recruit independent second-messenger systems (cAMP and Ca2+) that converge on the same somatotroph, the combined GH pulse is greater than either compound produces alone. Both clear quickly, so somatostatin tone returns between doses and the natural pulsatile GH rhythm is preserved.

Why Researchers Choose the Ipamorelin + CJC-1295 Blend

This GHRH plus GHRP combination is one of the most studied approaches to amplifying endogenous growth hormone. Pituitary somatotrophs sit at the crossing point of several regulatory inputs:

Stimulatory:

GHRH (via the GHRH receptor, Gs-coupled) raises cAMP and activates PKA
Ghrelin and GHRPs (via GHS-R1a, Gq-coupled) raise intracellular Ca2+ and drive vesicle exocytosis

Inhibitory:

Somatostatin (via SSTR, Gi-coupled) opposes cAMP and restrains release

CJC-1295 without DAC and Ipamorelin each engage one of the two stimulatory arms. When the GHRH receptor and GHS-R1a fire at the same time, the cAMP signal sensitises the secretory machinery while the calcium signal triggers vesicle fusion. Two independent amplification pathways converge on a single secretory event, so the GH pulse the blend produces is greater than either peptide can generate on its own.

Why the release stays pulsatile: CJC-1295 no DAC (roughly 30 minute half-life) and Ipamorelin (roughly 2 hour half-life) both clear quickly, so somatostatin tone returns between doses and the natural GH rhythm is maintained. This is the key contrast with CJC-1295 carrying the DAC modification (multi-day half-life), which holds GH elevated in a more constant, less pulsatile way.

Downstream Effects of a Stronger GH Pulse

IGF-1 output: every GH pulse stimulates hepatic IGF-1 synthesis, the main anabolic mediator
Fat metabolism: GH activates hormone-sensitive lipase in adipocytes, raising lipolysis
Protein synthesis: IGF-1 promotes mTOR signalling in muscle tissue
Sleep architecture: GH is secreted mainly during slow-wave sleep, and stronger pulses are linked to deeper SWS
Connective tissue: IGF-1 supports collagen synthesis in tendons and cartilage

Reconstitution and Kit Contents

Milo-Lab supplies the blend as a single 10mg vial containing 5mg CJC-1295 without DAC and 5mg Ipamorelin. Bacteriostatic water is sold separately.

Reconstitution: use bacteriostatic water; swirl gently until fully dissolved, do not shake. After reconstitution: keep refrigerated at 2-8°C, protected from light.

For research purposes only. Not for human consumption.

Vial & calculation

Calculate concentration and volume from the labelled amount, your final solution volume and a target amount you provide.

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Product FAQs

Customer Reviews

5.0 (3)

Good choice Good package

Thxw Verified

2026-09-09

Fast delivery, good customer support. product is clean.

Mr. S. Verified

2026-08-26

Works well, and give an effect for 1h

Ofer Verified

2026-08-26

Stacks Well With

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