Ipamorelin + CJC-1295 Blend
Ipamorelin + CJC-1295 (no DAC) is a GHRH/GHRP peptide blend that combines a GHRH receptor agonist with a ghrelin receptor (GHS-R1a) agonist.
1 × 10mg vial (5mg + 5mg)
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Half-Life
CJC-1295 no DAC: ~30min; Ipamorelin: ~2h
Combined Formulation
CJC-1295 no DAC (5mg) and Ipamorelin (5mg) in a single 10mg vial
Two Receptor Classes
GHRH receptor (Gs-coupled) and ghrelin receptor GHS-R1a (Gq-coupled)
Short Half-Lives
CJC-1295 no DAC ~30 min, Ipamorelin ~2 h
Mechanism of Action
Receptor Pharmacology of the Ipamorelin + CJC-1295 Blend
This blend combines a GHRH receptor agonist with a ghrelin receptor agonist. Pituitary somatotrophs sit at the crossing point of several regulatory inputs:
Stimulatory:
- GHRH (via the GHRH receptor, Gs-coupled) raises cAMP and activates PKA
- Ghrelin and GHRPs (via GHS-R1a, Gq-coupled) raise intracellular Ca2+ and drive vesicle exocytosis
Inhibitory:
- Somatostatin (via SSTR, Gi-coupled) opposes cAMP and restrains release
CJC-1295 without DAC and Ipamorelin each engage one of the two stimulatory arms. The two peptides act on separate receptors and second-messenger systems of the same cell type.
Half-Lives
CJC-1295 no DAC has a half-life of roughly 30 minutes and Ipamorelin of roughly 2 hours. CJC-1295 carrying the DAC modification, by contrast, has a multi-day half-life.
Downstream Signalling
Released growth hormone binds the GH receptor and signals through JAK2/STAT5, and hepatic IGF-1 expression follows.
Kit Contents and Storage
Milo-Lab supplies the blend as a single 10mg vial containing 5mg CJC-1295 without DAC and 5mg Ipamorelin.
Lyophilised vials: store at -20°C, protected from light.
For research purposes only. Not for human consumption.
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Related Products
CJC-1295 (no DAC)
CJC-1295 without DAC (Mod GRF 1-29) is a short-acting GHRH analogue that binds the pituitary GHRH receptor (Gs/cAMP) on somatotrophs.
Ipamorelin
Ipamorelin is a pentapeptide GHRP that binds the ghrelin receptor GHS-R1a without reported ACTH, cortisol or prolactin co-release in preclinical studies.
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