TB-500 research peptide – TB-500 is a synthetic Thymosin Beta-4 fragment, a regenerati
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TB-500

TB-500 is a synthetic Thymosin Beta-4 fragment, a regenerative research peptide that drives systemic tissue repair via actin regulation.

Recovery
In Stock

Total Price

฿1600

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For research & laboratory use only. Not for human consumption.

Half-Life

~8-10 days (systemic circulation)

Administration Route

Subcutaneous injection

Systemic Tissue Repair

Actin sequestration enables cell migration to injury sites

Cardiac Muscle Healing

Strong evidence in cardiac ischaemia and post-MI repair

Anti-Inflammatory

Downregulates TNF-α and IL-6 at wound sites

Effect Timeline

Start — Week 1

Systemic anti-inflammatory effect; reduced stiffness

Week 2

Improved mobility; cellular migration to damaged tissue

Week 4

Functional healing of soft tissue; muscle repair accelerated

Week 8

Full systemic tissue restoration; chronic injury improvement

Mechanism of Action

TB-500 reproduces the active region of Thymosin Beta-4 (TB4), a 43-amino-acid peptide expressed in almost every cell type. Its core function is binding free G-actin monomers, which fine-tunes actin polymerisation and lets cells migrate quickly toward sites of injury. Through this actin-regulating activity TB-500 mobilises repair cells systemically, increases expression of growth-factor receptors, and supports new blood-vessel formation (angiogenesis) by upregulating matrix metalloproteinases such as MMP-2. It also dampens local inflammation, with research linking Thymosin Beta-4 to reduced NF-kB signalling and lower pro-inflammatory cytokine output. Unlike locally acting compounds, TB-500 circulates and acts body-wide, which makes it a reference peptide for soft-tissue, cardiac and wound-healing models.

Scientific Research

Why Researchers Choose TB-500

TB-500 is the research-grade Thymosin Beta-4 fragment used wherever systemic, body-wide tissue repair is the question rather than a single injury site. By regulating actin and mobilising regenerative cells through the circulation, it has become a reference peptide across several repair-focused models:

  • Soft-tissue, tendon and ligament healing studies
  • Cardiac repair and post-ischaemic cardiomyocyte survival research
  • Wound healing and dermal regeneration models
  • Angiogenesis and endothelial progenitor cell mobilisation
  • Anti-inflammatory and cytokine-modulation investigations
  • Neuro-repair work, including oligodendrocyte differentiation and myelination

TB-500 vs BPC-157: Complementary Repair Pathways

TB-500 and BPC-157 are among the most frequently co-administered repair peptides in research because they act through distinct mechanisms that overlap well:

MechanismBPC-157TB-500
AngiogenesisVEGF upregulationMMP-2, VEGF
Cell migrationFAK-PaxillinActin sequestration
Primary targetLocal (injury site)Systemic
Half-life~4 hours~8-10 days

BPC-157 concentrates on local vascular and fibroblast activity at the injury site, while TB-500 mobilises repair cells throughout the body. Used together they cover both ends of the healing cascade. See the BPC-157 + TB-500 Combo for bundled pricing.

Reconstitution and Storage

Reconstitution: use bacteriostatic water; swirl gently until dissolved, do not shake. After reconstitution: store refrigerated, use within 30 days, and protect from direct light.

For research purposes only. Not for human consumption.

Dosing at a Glance

Route

Subcutaneous injection

Frequency

2x weekly (load), 1x weekly (maint.)

Typical research dose

2–5 mg

Calculate dosage

Opens the calculator with this peptide preselected. Research reference only.

Product FAQs

Stacks Well With

Used in Research Stacks

Recovery & Repair Stack

BPC-157 500 mcg TB-500 2.5 mg
View Stack Research

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