SLU-PP-332

Why Researchers Choose SLU-PP-332

SLU-PP-332 is a synthetic estrogen-related receptor (ERR) pan-agonist. It binds ERR alpha, beta and gamma and is studied in nuclear-receptor transcription and in the PGC-1 alpha coactivator pathway that governs oxidative-metabolism gene expression. Research interest centres on:

• Mitochondrial biogenesis gene programmes in preclinical models
• ERR-mediated transcription of oxidative-metabolism genes in preclinical work
• Fatty-acid oxidation pathways downstream of nuclear-receptor activation
• PGC-1 alpha coactivator interaction with ERR family members
• Comparison of nuclear-receptor transcription with cell-surface receptor signalling

Because SLU-PP-332 acts through nuclear-receptor transcription, it is a mechanistically distinct tool compared with GLP-1 or GLP-1/GIP peptides.

ERR Signalling

ERR receptors are orphan nuclear receptors that coordinate the transcription of genes for oxidative phosphorylation, mitochondrial assembly and fatty-acid catabolism. In preclinical models, engagement of ERR by SLU-PP-332 is associated with:

1. Amplification of the PGC-1 alpha coactivator program
2. Increased markers of mitochondrial biogenesis
3. A shift in gene expression towards fatty-acid oxidation

Storage

Lyophilised vials: store at -20°C, protected from light. Capsule packs: store in a cool, dry place away from light.

For research purposes only. Not for human consumption.