Retatrutide
Retatrutide (LY3437943) is Eli Lilly's investigational triple-receptor peptide targeting GLP-1, GIP and glucagon, with up to 24.2% weight loss in Phase 2.
Total Price
฿2800
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For research & laboratory use only. Not for human consumption.
Retatrutide Starter Pack
- Retatrutide฿2800
- Bacteriostatic Water 10ml฿300
- Insulin Syringes 1ml (10-Pack)฿100
Everything to get started — discount applied automatically at checkout.
Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries
Half-Life
6 days
Administration Route
Subcutaneous injection
Triple Receptor Agonist
Targets GLP-1, GIP & glucagon for maximum metabolic effect
24.2% Body Weight Loss
Exceeds semaglutide & tirzepatide in Phase 2 head-to-head
Liver Fat Reduction
Glucagon receptor activation directly drives hepatic lipolysis
Effect Timeline
Appetite suppression kicks in; gastric emptying slows
4–6% weight loss; liver fat begins reducing
Visceral fat visibly reduced; energy expenditure elevated
12–16% weight loss; metabolic rate measurably increased
Start — Week 1–2
Appetite suppression kicks in; gastric emptying slows
Week 4
4–6% weight loss; liver fat begins reducing
Week 8
Visceral fat visibly reduced; energy expenditure elevated
Week 16
12–16% weight loss; metabolic rate measurably increased
Mechanism of Action
Scientific Research
N Engl J Med (2023)
Why Researchers Choose Retatrutide
Retatrutide is the first triple-receptor agonist to reach late-stage metabolic research, and it is studied wherever maximum incretin efficacy matters:
- Tri-receptor pharmacology and additive receptor-engagement studies
- Maximum-efficacy weight-reduction protocols beyond GLP-1 and GLP-1/GIP agonists
- Head-to-head efficacy modelling against semaglutide and tirzepatide
- Energy-expenditure and thermogenesis pathway investigations
- Hepatic lipid metabolism and non-alcoholic steatohepatitis (NASH) research
- Metabolic flexibility and substrate-utilisation studies
How Retatrutide Works
Retatrutide activates three metabolic receptors simultaneously: GLP-1, GIP and glucagon. The GLP-1 and GIP arms work much like tirzepatide, driving glucose-dependent insulin secretion, slowing gastric emptying and suppressing appetite. The addition of glucagon receptor activation is what sets it apart: in the liver, glucagon signalling raises fatty-acid oxidation and lifts basal metabolic rate, so retatrutide acts on energy expenditure as well as energy intake. Because the simultaneous GLP-1 signal offsets glucagon’s glucose-raising effect, the net result in trials was increased calorie burn without harmful blood-sugar elevation, the mechanism behind the up-to-24.2% weight reductions seen in Phase 2.
Retatrutide vs. Semaglutide and Tirzepatide
Retatrutide is a GLP-1, GIP and glucagon triple agonist, one step beyond tirzepatide (dual GLP-1/GIP) and semaglutide (GLP-1 only). The added glucagon axis is why it produced the largest Phase 2 weight loss of the three, though no direct head-to-head trial has been published and Phase 3 studies are ongoing.
Retatrutide Dosing Protocol
Titration: escalate once weekly, roughly every 4 weeks, from 1mg to a 4mg maintenance dose, then up to 8mg or 12mg. The 8mg and 12mg arms produced the greatest weight loss in trials.
Reconstitution and Storage
Reconstitution: use bacteriostatic water (1 to 2ml per vial); swirl gently until fully dissolved, do not shake. After reconstitution: keep refrigerated (2-8°C), use within 28 days, do not freeze, and protect from direct light.
Further Reading
Dosing at a Glance
Route
Subcutaneous injection
Frequency
Once weekly
Typical research dose
0.5–12 mg
Opens the calculator with this peptide preselected. Research reference only.
Product FAQs
Customer Reviews
Used for weight loss. It works as advertised. Using the minimal dosage have lost 21 pounds in 90 days
Fast delivery, great support. The product looks clean and now needs to be tested. Reconstitution went smoothly.
I work perfectly lose 10kg
Excellent quality. Followed the useage guide provided on the website. Noticeable reduction in appetite. The easiest cut I’ve ever done dropped 8kg bodyfat and had very little side effects. A tiny bit of digestive discomfort first few weeks that’s it. Highly recommend and the customer service here is fantastic.
Excellent product. I have been unable to exercise after a motorbike accident and have still been keeping trim. I can't weigh myself until I go to the gym, but I've had to add another hole to my shorts belt. I now take 2mg a week with no nausea. Painless injections with BAC water, much better than saline, which causes irritation at the injection site.
Crazy good. Taking a moderately low dose of 1mg weekly and have zero desire to eat anything bad for me. Sticking to a 700 calorie deficit with ease. Super fast shipping and great owner too!