Tesofensine (development code NS2330) is a small-molecule triple monoamine reuptake inhibitor acting at the dopamine, noradrenaline and serotonin transporters. It is supplied in capsule form for laboratory research, not as a peptide.

What is its half-life?

Approximately nine days in published pharmacokinetic studies, among the longest of the monoamine reuptake inhibitors.

How is it supplied and verified?

In sealed capsules at the stated content per unit, with a certificate of analysis reporting purity and identity, available on request before ordering.

How should it be stored?

Sealed, dry, at room temperature and protected from light and humidity. No reconstitution is required.

Tesofensine

Name: Tesofensine
Brand: Milo-Lab
Availability: InStock

Tesofensine (NS2330) is an orally available triple monoamine reuptake inhibitor at the DAT, NET and SERT transporters. Research compound.

MetabolicMitochondrial

In Stock

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1 capsule · 500 mcg total

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Total Price

฿3400

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For research & laboratory use only. Not for human consumption.

Shipping: free within Thailand, ฿700 worldwide. Added at checkout. Delivery times & countries

Half-Life

~9 days

Mechanism of Action

Tesofensine (development code NS2330) is a centrally-acting triple monoamine reuptake inhibitor that blocks the presynaptic transporters for noradrenaline (NET), dopamine (DAT) and serotonin (SERT). Blocking reuptake raises the synaptic concentration of all three monoamines. It was originally developed as a candidate for Parkinson's and Alzheimer's disease. Its plasma half-life of roughly nine days is among the longest in this compound class. Unlike the incretin peptides it is a small molecule and orally available.

Scientific Research

Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

The Lancet (2008)

Why Researchers Choose Tesofensine

Tesofensine (NS2330) is one of the few orally active monoamine reuptake inhibitors with Phase 2 clinical data, which makes it a practical research tool wherever a small-molecule alternative to peptide pharmacology is studied:

Appetite-regulation and satiety-signalling studies
Triple monoamine (noradrenaline, dopamine, serotonin) reuptake pharmacology
Oral versus injectable weight-management comparisons against GLP-1 agonists
Resting energy-expenditure and metabolic-rate investigations
Reward-driven and craving-related eating behaviour research

Storage

Storage: keep capsules cool, dry and away from direct light and moisture; keep tightly sealed and away from heat.

Stacking

Tesofensine is generally used as a standalone oral agent in metabolic research. In comparative studies it is occasionally evaluated alongside GLP-1 receptor agonists to contrast small-molecule central pharmacology with peptide incretin pathways.

Vial & calculation

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