Tesofensine research peptide – Tesofensine (NS2330) is an oral triple monoamine reuptake in

Tesofensine

Tesofensine (NS2330) is an oral triple monoamine reuptake inhibitor that suppresses appetite and supports weight management research.

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฿3400

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For research & laboratory use only. Not for human consumption.

Half-Life

~9 days

Administration Route

Oral capsule

Appetite Control

Triple monoamine reuptake inhibition suppresses hunger

Energy Expenditure

Modestly increases resting metabolic rate

Once-Daily Oral

Long half-life allows simple once-daily oral dosing

Effect Timeline

Start — Week 2

Reduced appetite and food cravings

Week 4

Early fat loss as energy intake falls

Week 12

Substantial weight reduction in clinical research

Mechanism of Action

Tesofensine (development code NS2330) is a centrally-acting triple monoamine reuptake inhibitor that blocks the presynaptic reuptake transporters for noradrenaline, dopamine and serotonin. With reuptake inhibited, these three neurotransmitters accumulate in the synapse: elevated serotonin and noradrenaline drive satiety and appetite suppression, dopamine reinforces reward-related eating control, and the combined adrenergic tone modestly lifts resting energy expenditure. Originally developed for Parkinson's and Alzheimer's disease, it produced unexpectedly large weight loss in clinical research, which is why it is now studied as an oral, non-injectable tool for appetite regulation and metabolic investigation. Unlike GLP-1 peptides, tesofensine is orally active and acts on the central nervous system rather than incretin receptors.

Scientific Research

Why Researchers Choose Tesofensine

Tesofensine (NS2330) is one of the few orally active, non-injectable appetite-suppression compounds with Phase 2 clinical data, which makes it a practical research tool wherever a peptide-free, central-nervous-system approach to weight management is needed:

  • Appetite-regulation and satiety-signalling studies
  • Triple monoamine (noradrenaline, dopamine, serotonin) reuptake pharmacology
  • Oral versus injectable weight-management comparisons against GLP-1 agonists
  • Resting energy-expenditure and metabolic-rate investigations
  • Reward-driven and craving-related eating behaviour research

Storage

Storage: keep capsules cool, dry and away from direct light and moisture; keep tightly sealed and away from heat.

Stacking

Tesofensine is generally used as a standalone oral agent in appetite and metabolic research. In comparative studies it is occasionally evaluated alongside GLP-1 receptor agonists to contrast oral central-acting suppression with injectable incretin pathways.

Dosing at a Glance

Route

Oral capsule

Frequency

Once daily (oral capsule)

Typical research dose

250–500 mcg

Calculate dosage

Opens the calculator with this peptide preselected. Research reference only.

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