CJC-1295 (no DAC)

Why Researchers Choose CJC-1295 No DAC

CJC-1295 without DAC, the Modified GRF 1-29 peptide, is one of the most studied short-acting GHRH analogues in performance and recovery research. Its appeal is the way it raises growth-hormone output while keeping the body’s natural pulsatile rhythm intact, which makes it a frequent reference compound wherever physiological GH signalling matters:

• Pulsatile growth-hormone release and somatotroph signalling studies
• Muscle protein synthesis, recovery and lean-mass research
• Lipolysis and body-composition (fat-loss) investigations
• GHRH receptor sensitivity and tachyphylaxis comparisons against DAC-bound analogues
• Synergy modelling with GHRP secretagogues such as ipamorelin

The Four Amino-Acid Substitutions

Mod GRF 1-29 differs from native GHRH(1-29), the same active fragment marketed as Sermorelin, at four positions. Each change closes a specific degradation pathway:

1. Position 2: Ala to D-Ala, which resists DPP-IV cleavage at the N-terminus
2. Position 8: Asn to Gln, which prevents asparagine deamidation
3. Position 15: Gly to Ala, which reduces flexibility at a vulnerable site
4. Position 27: Met to Leu, which prevents methionine oxidation

Together these substitutions extend the half-life from roughly 7 minutes for Sermorelin to about 30 minutes for CJC-1295 no DAC, with equivalent or better receptor potency.

CJC-1295 Plus Ipamorelin: The Gold-Standard Combination

Pairing a GHRH analogue (CJC-1295 no DAC) with a GHRP (ipamorelin) is one of the most widely researched growth-hormone secretagogue protocols, because the two compounds act on different receptors that converge on the same cells.

Why the combination works:

• The GHRH receptor (Gs-coupled) raises cAMP and amplifies GH synthesis and release
• The ghrelin receptor GHS-R1a (Gq-coupled) raises intracellular Ca2+ and triggers GH granule exocytosis
• Both signals reach the same pituitary somatotroph cells, so the combined GH release is well above additive

Advantages over the CJC-1295 with DAC plus ipamorelin pairing:

• A more physiological, pulsatile GH pattern
• Better maintenance of GHRH receptor sensitivity
• Tighter control over injection timing

See our CJC-1295 + Ipamorelin Combo for bundled pricing.

Reconstitution and Storage

Reconstitution: use bacteriostatic water; swirl gently until dissolved, do not shake. After reconstitution: keep refrigerated (2-8°C) and use within 30 days.

For research purposes only. Not for human consumption.

Further Reading

• Growth Hormone Secretagogues Compared